Can blisters on the skin mean allergy to a medication?

Bullous Pemphigoid with secondary bacterial infection. Caused by an allergy to hydrochlorthiazide diuretic.
Bullous Pemphigoid with secondary bacterial infection. Caused by an allergy to hydrochlorthiazide diuretic.

Yes. In particular there is a condition known as bullous pemphigoid. This eruption consists of blisters scattered over different parts of the body. It is considered to be either a drug  (medication) rash or one that is autoimmune (not caused by medication but by the body’s own immune process).

The most common class of drugs that cause bullous pemphigoid are the sulfa drugs. These drugs can range from certain diuretics, antibiotics, anti-inflammatory drugs to diabetic medications. The rash is extremely itchy. This eruption can also develop a secondary bacterial infection resulting in crusted lesions scattered all over the body.

Bullous pemphigoid must be treated by eliminating the offending medication, as well as topical and systemic therapy.

– Dr. Bussell

Beverly Hills Dermatology Consultants

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